منابع مشابه
Cellular plasticity for group I mGluR-mediated epileptogenesis.
Stimulation of group I metabotropic glutamate receptors (mGluRs) by the agonist (S)-dihydroxyphenylglycine in the hippocampus transforms normal neuronal activity into prolonged epileptiform discharges. The conversion is long lasting in that epileptiform discharges persist after washout of the inducing agonist and serves as a model of epileptogenesis. The group I mGluR model of epileptogenesis t...
متن کاملAstrocytic group I mGluR dependent potentiation of astrocytic glutamate
34 One of the most important functions of astrocytes is removal of glutamate released 35 during synaptic transmission. Surprisingly, the mechanisms by which astrocyte 36 glutamate uptake is acutely modulated remain to be clarified. Astrocytes express 37 metabotropic glutamate and other G protein-coupled receptors (GPCRs) which are 38 activated during neuronal activity. Here we test the hypothes...
متن کاملExtracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
Stimulation of group I mGluRs elicits several forms of translation-dependent neuronal plasticity including epileptogenesis. The translation process underlying plasticity induction is controlled by repressors including the fragile X mental retardation protein (FMRP). In the absence of FMRP-mediated repression, a condition that occurs in a mouse model (Fmr1(-/-)) of fragile X syndrome, group I mG...
متن کاملCONTRASTING ROLES OF PROTEIN KINASE C IN INDUCTION vs. SUPPRESSION OF GROUP I mGluR-MEDIATED EPILEPTOGENESIS IN VITRO
Activation of group I metabotropic glutamate receptors (mGluRs) elicits persistent ictaform discharges in guinea pig hippocampal slices, providing an in vitro model of epileptogenesis (Merlin and Wong 1997). The induction of these persistent ictaform bursts is prevented by Lcysteine sulfinic acid (CSA), an agonist at phospholipase D (PLD)-coupled mGluRs (Rico and Merlin 2004). Studies described...
متن کاملContrasting roles of protein kinase C in induction versus suppression of group I mGluR-mediated epileptogenesis in vitro.
Activation of group I metabotropic glutamate receptors (mGluRs) elicits persistent ictaform discharges in guinea pig hippocampal slices, providing an in vitro model of epileptogenesis. The induction of these persistent ictaform bursts is prevented by l-cysteine sulfinic acid (CSA), an agonist at phospholipase D (PLD)-coupled mGluRs. Studies described herein examined the role of protein kinase C...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2010
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2010.02802.x